Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production
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چکیده
منابع مشابه
Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production.
The copper chaperone for superoxide dismutase (CCS) binds to both the β-site AβPP cleaving enzyme (BACE1) and to the neuronal adaptor protein X11α. BACE1 initiates AβPP processing to produce the amyloid-β (Aβ) peptide deposited in the brains of Alzheimer's disease patients. X11α also interacts directly with AβPP to inhibit Aβ production. However, whether CCS affects AβPP processing and Aβ produ...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2010
ISSN: 1875-8908,1387-2877
DOI: 10.3233/jad-2010-100717